摘要
目的:基于GEPIA数据库分析正常胃组织与胃癌组织差异表达基因及其对胃癌患者生存预后的影响.方法:利用GEPIA数据库来获取胃癌组织和正常组织的差异基因,然后在GEPIA平台上确认筛选出的基因并对其进行生存预后分析.结果:通过GEPIA数据库分析得到差异表达基因4 644个,其中排在前 10 位的基因分别为:PRR11、CLDN7、TPX2、GNL3L、SKA3、ADHFE1、MTDH、CEP55、KIF11、KIF20B.其中ADHFE1基因与胃癌患者生存预后呈负相关,CEP55基因与胃癌患者生存预后呈正相关.结论:胃癌组织与正常组织之间存在差异表达基因,其中ADHFE1基因和CEP55基因对胃癌患者的生存预后推断具有重要价值.
Abstract
Objective:To analyze the differentially expressed genes between normal gastric tissues and gastric cancer and the influence of differentially expressed genes on the survival and prognosis of patients with gastric cancer based on GEPIA data-base.Methods:The top differential genes between normal and gastric cancer tissues were obtained from GEPIA database,and the screened genes were verified on GEPIA website for prognostic analysis.Results:A total of 4 644 differentially expressed genes were identified in GEPIA database.The top 10 genes were PRR11,CLDN7,TPX2,GNL3L,SKA3,ADHFE1,MTDH,CEP55,KIF11,and KIF20B.ADHFE1 gene was negatively correlated with the survival and prognosis of gastric cancer pa-tients,while CEP55 gene was positively correlated with the survival and prognosis of gastric cancer patients.Conclusion:There are differential genes between gastric cancer and normal tissues,and ADHFE1 and CEP55 genes may play an important role in the survival and prognosis of gastric cancer.
国家科技期刊平台
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万方数据