Research progress on natural products of Li medicine in improving MAFLD by the AMPK pathway
Metabolism-associated fatty liver disease(MAFLD)is the hepatic manifestation of metabolic syndrome,with a global incidence up to 25%in adults,and has replaced viral hepatitis as the first chronic liver disease in China.Adenosine mono-phosphate-activated protein kinase(AMPK)is an important key enzyme in the regulation of glycolipid metabolism in vivo.The ac-tivation of AMPK is thought to have the ability to improve glucose and lipid metabolism disorder,alleviate oxidative stress,pos-sess anti-inflammatory,regulate autophagy affects,and protect the mitochondria to play a therapeutic role in the treatment of MAFLD.As an important treasure trove of medicinal resources in traditional Chinese medicine,natural products of Li medicine have been widely found to activate AMPK and exhibit excellent effects in improving MAFLD.Therefore,this review is planned to summarize the association mechanisms between MAFLD improvement and AMPK activation of Li medicine and its natural prod-ucts,to provide theoretical references for the exploration and development of Li medicine and its natural products.There by pro-moting modernization industry development of Li medicine.
Li medicineNatural products of Li medicineAMPKMAFLD
国家科技期刊平台
NSTL
万方数据
