牙周炎与炎症性肠病的微生物/免疫关系研究进展
Research progress on the relationship between periodontitis and inflammatory bowel disease
王慧 1李永辉 2钟晓雪 1陈敏哲 1薛逢明 1贺小宁1
作者信息
- 1. 海南医学院第二附属医院口腔科,海南 海口 570100
- 2. 海南医学院,海南 海口 570100
- 折叠
摘要
牙周炎合并炎症性肠病(IBD)为口腔科的常见疾病,二者发在发病过程中均受到微生物群失调和免疫反应的影响,形成病理上相互促进,导致疾病的逐渐恶化.近年来的研究表明牙周炎和IBD之间存在密切的联系,主要包括直接途径和间接途径.直接途径为促炎微生物从口腔转位到肠道,并刺激肠道免疫.间接途径包括系统性的免疫激活,并可能伴有非特异性的免疫功能.本综述对近年来牙周炎和IBD之间的微生物/免疫相互作用进行了概述,总结了牙周炎和IBD之间复杂的致病关系,为牙周炎合并IBD的治疗提供指导.
Abstract
Periodontal disease combined with inflammatory bowel disease(IBD)is a common disease in the department of stomatology.Both of them are affected by the imbalance of microbiota and immune reaction in the process of onset,forming a path-ological mutual promotion,leading to the gradual deterioration of the disease.Recent studies have shown that there is a close rela-tionship between periodontal disease and IBD,including direct and indirect pathways.The direct pathway is the translocation of pro-inflammatory microorganisms from the oral cavity to the intestine,and the stimulation of intestinal immunity.Indirect path-ways include systemic immune activation and may be accompanied by non-specific immune function.This paper reviewes the micro-bial/immune interaction between periodontal disease and IBD in recent years,and summarizes the complex pathogenic relationship between periodontal disease and IBD,providing guidance for the treatment of Periodontal disease with IBD.
关键词
牙周炎/炎症性结肠炎/微生物/免疫反应Key words
Periodontitis/Inflammatory bowel disease/Microbe/Immune response引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据