Value of early biomarkers in differential diagnosis of viral and bacterial sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection,which can be caused by a broad range of pathogens,usually represented by bacteria.In recent years,sepsis caused by viruses is often ignored,until the outbreak of COVID-19,whose severity made viral sepsis the focus of global attention.Biomarkers play an important role in the early diagnosis of sepsis.Due to the challenge of identifying the pathogen,a biomarker that can broadly distinguish viral from bacterial infections in the early stages of sepsis development has been lacking clinically.This leads to antimicrobial resistance.Therefore,this article reviews the value of procalcitonin,C-reactive protein,serum amyloid A,CD64 and calprotectin in the early differentiation of viral and bacterial sepsis,in order to provide reference for clinical medical workers and improve the understanding of viral sepsis.
万方数据
维普
