Advances in membrane induction technique combined with Ca(OH)2-PMMA for the treatment of segmental bone defects
Segmental bone defects is a high-burden and challenge,with etiologies including trauma,infection,and tumors.Currently,the main reconstruction methods for bone defects include vascularized bone grafting,bone handling,and membrane-induced techniques(Masquelet technique).Although vascularized autologous bone graft is considered the gold standard for reconstruction of large-sized bone defects,it has limitations such as high professionalism,long treatment period,and complexi-ty,compared to the membrane-induced technique,which has been widely used in the treatment of bone defects due to its simplici-ty,efficiency,and reliability.Membrane-induction technique is recognized as an effective method for the treatment of segmental bone defects at home and abroad,as it promotes the growth and healing of new bone at the defect site by obtaining a biologically ef-fective induced membrane through two surgeries.In this paper,we will outline the current status of bone defects,introduce the concept of critical-size bone defects,and discuss the clinical significance of combining the novel material of polymethylmethacrylate calcium hydroxide mixture[Ca(OH)2-PMMA]in the Masquelet technique for the treatment of segmental bone defects.
Bone defectsCritical sizeMembrane induction techniqueCa(OH)2-PMMA
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