Research advances in molecular biological abnormalities affecting the prognosis of multiple myeloma
Multiple myeloma is a plasma cell tumor characterized by monoclonal plasma cell dysplasia and multifocal bone in-volvement.It mainly occurs in middle-aged and elderly people.Although proteasome inhibitors,immunomodulators and hemato-poietic stem cell transplantation have improved the survival rate of patients,MM is still incurable.In recent years,due to the wide application of molecular biological detection technologies such as karyotype analysis,FISH,flow cytometry,liquid biopsy,etc.,the diagnostic rate of MM has been greatly improved.At the same time,many gene abnormalities related to the prognosis of MM have been found successively.
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