胆固醇在肝细胞癌中的作用及治疗潜在价值
Role of cholesterol in hepatocellular carcinoma and its potential therapeutic value
曾阳玲 1王运踊 1关海梅 1王恬雯 1谢宝华 1李国宝 1张日云 1毛德文2
作者信息
- 1. 广西中医药大学,广西 南宁 530001
- 2. 广西中医药大学第一附属医院肝病科,广西 南宁 530023
- 折叠
摘要
肝细胞癌(HCC)是最常见的原发性肝脏恶性肿瘤,其特点是死亡率高,易转移和复发,五年生存率低,临床预后差.目前几乎没有直接靶向肿瘤细胞的治疗方法,最有效的HCC治疗方法是针对肿瘤免疫微环境.肿瘤细胞比较明显的特征是代谢异常,用以满足与肿瘤快速生长相关的高能量和生物合成需求.随着研究的不断深入,发现胆固醇通常富集在肿瘤微环境中,肝脏胆固醇代谢参与HCC的发生发展过程.因此,探索肝脏中胆固醇代谢的分子调控过程,阐明胆固醇在HCC中的作用,并寻求治疗HCC的潜在靶点,是目前备受关注的重要科研问题之一.本文就胆固醇在HCC中的作用及治疗潜在价值作简要综述,为进一步研究和深入探讨胆固醇和HCC之间的关系提供有力证据.
Abstract
Hepatocellular carcinoma(HCC)is the most common primary malignant liver tumor,which is characterized by high mortality,easy metastasis and recurrence,low 5-year survival rate and poor clinical prognosis.At present,there are few treat-ments that directly target tumor cells.The most effective treatment for HCC is targeting the tumor immune microenvironment.Tu-mor cells are characterized by metabolic abnormalities to meet the high energy and biosynthesis needs associated with rapid tumor growth.With the deepening of research,it has been found that cholesterol is usually enriched in the tumor microenvironment,and liver cholesterol metabolism is involved in the occurrence and development of HCC.Therefore,exploring the molecular regulation process of cholesterol metabolism in the liver,elucidating the role of cholesterol in HCC,and seeking potential targets for the treat-ment of HCC is one of the important scientific research issues that have attracted much attention.This article briefly reviews the role of cholesterol in HCC and its potential therapeutic value,and provides strong evidence for further research and in-depth discus-sion of the relationship between cholesterol and HCC.
关键词
胆固醇/代谢调控/肝细胞癌/治疗靶点Key words
Cholesterol/Metabolism regulation/Hepatocellular carcinoma/Therapeutic targets引用本文复制引用
基金项目
国家自然科学基金项目(82360912)
国家自然科学基金项目(81960841)
国家自然科学基金项目(82274434)
出版年
2024
国家科技期刊平台
NSTL
万方数据