纳米药物递释系统在胃癌治疗中的研究进展
Advances of nanodrug delivery system in gastric cancer treatment
黄克祥 1曹坤 1张俊伟 1焦斌琪 1梁月祥 1陈铭哲 1张彦志 1李井泉1
作者信息
- 1. 海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100;海南医学院,海南 海口 570100
- 折叠
摘要
胃癌是最常见的消化道肿瘤之一,发病率居第五位,死亡率居第三位.手术依然是唯一可能治愈胃癌的方法,然而,即便接受根治性切除,绝大多数患者仍然出现肿瘤复发,5年生存率仅为30%.辅助化疗在胃癌术后治疗中起主导作用,化疗虽然可以进一步提高胃癌患者生存,但其副反应发生率高、且需全身多次反复给药.针对传统化疗存在的弊端,开发缓释化疗制剂成为肿瘤治疗领域的热点,其中纳米药物递释系统在缓释化疗方面具有明显的优势.本文对胃癌治疗中纳米药物递释系统的研究进展进行综述.
Abstract
Gastric cancer is one of the most common digestive tract tumors,with the fifth highest incidence rate and the third highest mortality rate.Surgery remains the only possible cure for gastric cancer,however,even after radical resection,the vast majority of patients still experience tumor recurrence and the 5-year survival rate is only 30%.Adjuvant chemotherapy plays a lead-ing role in postoperative treatment of gastric cancer.Although chemotherapy can further improve the survival of gastric cancer pa-tients,it has a high incidence of side effects and requires repeated systemic administration.In view of the drawbacks of traditional chemotherapy,the development of extended-release chemotherapeutic agents has become a hotspot in the field of tumor treat-ment,among which the nanodrug delivery system has obvious advantages in extended-release chemotherapy.In this paper,the re-search progress of nano drug delivery system in gastric cancer treatment is reviewed.
关键词
纳米技术/药物递送系统/胃癌/疗法Key words
Nanotechnology/Drug Delivery System/Gastric Cancer/Therapy引用本文复制引用
基金项目
海南省科学技术厅重点研发项目(ZDYF2020137)
出版年
2024
国家科技期刊平台
NSTL
万方数据