Wnt/β-catenin pathway regulates iron death in hepatocellular carcinoma
Iron death is considered to be an iron-dependent,non-apoptotic form of regulated cell death,which is mainly trig-gered by reactive oxygen species(ROS)production and imbalance of iron homeostasis leading to severe lipid peroxidation,and it induces related factors that can directly or indirectly affect glutathione peroxidase through different pathways,leading to decreased antioxidant capacity and accumulation of lipid reactive oxygen species(ROS)in the cells,and ultimately leading to oxidative cell death.Meanwhile,iron death is regulated by various pathways,such as iron metabolism,mitochondrial activity,redox homeosta-sis,and disease-related signalling pathways.It has been reported that dysregulation of iron death metabolic pathways can affect the development and progression of hepatocellular carcinoma.Little is known about the molecular mechanisms by which iron death leads to disease,but iron death-related genes and pathways are associated with hepatocellular carcinoma progression.It was found that abnormal activation of the Wnt/β-catenin signalling pathway is associated with recurrence,invasion,metastasis and immune escape of hepatocellular carcinoma,and is closely linked to iron death.This pathway can further aggravate the progression of hepa-tocellular carcinoma by regulating the occurrence of iron death.Some substantial progress has been made in this field in hepatocellu-lar carcinoma.Therefore,in the present review,we will explore the process of iron death by outlining its molecular mechanism and its role in hepatocellular carcinoma,and at the same time,we will specifically analyse the Wnt/β-catenin signaling pathway to regulate the process of iron death,so as to provide a reliable scientific theoretical basis for the treatment of hepatocellular carcino-ma in the future.
国家科技期刊平台
NSTL
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