TBI后应激性肠屏障损害的研究进展
Research progress on stress induced intestinal barrier damage after TBI
叶敏 1杨文菲 1王丹心 2周建 2谭绍英 2谢碧姣 1李玉敏 1许铃 1孙海 1王涛1
作者信息
- 1. 海南医学院,海南 海口 571199
- 2. 海南医学院第一附属医院,海南 海口 570100
- 折叠
摘要
创伤性脑损伤后应激性肠屏障损害增加了患者的死亡风险,严重影响疾病预后,目前其发病机制和治疗策略仍不完全清楚.本文旨在总结创伤性脑损伤应激性肠屏障损害的病理机制和保护策略等关键问题的研究进展,发现肠上皮细胞通透性增加、紧密连接、内质网应激、细胞自噬、缺血-再灌注损伤可能是创伤性脑损伤应激后肠屏障损害的主要机制.此外,本文还综述了迷走神经刺激、益生菌、外源性补充饥饿素、氧疗等对创伤性脑损伤后应激性肠屏障损害的保护作用.本文将为探索精准有效的创伤性脑损伤后应激性肠屏障损害防治提供新视角和干预靶点.
Abstract
Stress induced intestinal barrier damage after traumatic brain injury significantly increases the risk of mortality in pa-tients and seriously affects disease prognosis.However,the pathogenesis and treatment strategies are still not fully understood.This article aims to summarize the research progress on key issues such as the pathological mechanism and protective strategies of stress induced intestinal barrier damage in traumatic brain injury,it points out that increased permeability of intestinal epithelial cells,tight junctions,endoplasmic reticulum stress,autophagy,and ischemia-reperfusion injury may be the main mechanisms of intestinal barrier damage after traumatic brain injury.This article reviews the protective effects of vagus nerve stimulation,probiot-ics,exogenous supplementation of hunger hormone,and oxygen therapy on stress induced intestinal barrier damage after traumatic brain injury.This article will provide a new perspective and intervention targets for exploring precise and effective prevention and treatment of stress induced intestinal barrier damage after traumatic brain injury.
关键词
创伤性脑损伤/肠屏障损害/病理机制/保护策略/研究进展Key words
Traumatic brain injury/Intestinal barrier damage/Pathological mechanism/Strategies for protection/Research progress/Summary引用本文复制引用
基金项目
海南省自然科学基金资助项目(822RC833)
海南省自然科学基金资助项目(820RC622)
海南省研究生创新课题基金资助项目(Qhys2023-465)
出版年
2024
国家科技期刊平台
NSTL
万方数据