N6-methyladenosine(m6A)modification of RNA is the most common internal epigenetic modification mode in eu-karyotic mRNA,has been recognized as a key regulator of tumor and immune system,which is widely involved in the regulation of tumor treatment resistance,tumor microenvironment,tumor immune escape,and tumor metabolism.The specific regulatory mechanisms of m6A modification and tumor immune escape need to be further explored,mainly through direct regulation of im-mune cells or indirect regulation of tumor cells to affect the immune response and play a role as a regulator of tumor immune es-cape.This paper reviews the possible mechanisms of m6A modification in the process of tumor immune escape,which is to im-prove the application prospect of m6A modification and related modulators in tumor immunotherapy.
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