基于肿瘤微环境探讨免疫检查点治疗在前列腺癌的应用及进展
Exploring the application and progress of immune checkpoint therapy in prostate cancer based on the tumor microenvironment
苏超 1揭育祯 1王飞2
作者信息
- 1. 海南医科大学临床学院,海南 海口 571199;海南医科大学附属海南医院泌尿外科,海南 海口 570000
- 2. 海南医科大学附属海南医院泌尿外科,海南 海口 570000
- 折叠
摘要
前列腺癌是男性最常见的癌症之一,前列腺癌患者的肿瘤微环境(TME)通常具有抑制免疫反应的特征,包括T细胞功能受损、免疫抑制性细胞浸润以及免疫检查点的过度表达,因此改善TME对于提高免疫治疗效果至关重要.免疫监测、基因组学分析和TME特征的评估可以确定最适合患者的治疗方案.然而,治疗效果因患者差异较大,个体化治疗策略显得尤为关键.本综述深入探讨了前列腺癌的免疫治疗策略,特别是针对TME的干预和个体化治疗策略,以及多层次的治疗组合,旨在为前列腺癌患者提供新的治疗思路和方法,从而提高其生存率和生活质量,为这一常见癌症的治疗提供有力的理论依据.
Abstract
Prostate cancer is one of the most common cancers in men,and the tumor microenvironment(TME)of prostate cancer patients usually features immunosuppressive properties,including impaired T-cell function,infiltration of immunosuppres-sive cells,and overexpression of immune checkpoints.Therefore,improvement in the TME is crucial for enhancing the effective-ness of immunotherapy.Therapy plans best suited to individual patients can be determined through immune monitoring,genomic analysis,and assessment of TME characteristics.However,due to significant differences between individual patients,personal-ized treatment strategies become particularly important.This review delves into the immunotherapy of prostate cancer,especially the intervention and individualized treatment strategies for TME,as well as the multilevel therapeutic combinations.It aims to pro-vide new therapeutic ideas and methods for prostate cancer patients so as to improve their survival rate and quality of life,and to provide a strong theoretical basis for the treatment of this common cancer.
关键词
前列腺癌/免疫检查点治疗/肿瘤微环境Key words
Prostate cancer/Immune checkpoint therapy/Tumor microenvironment引用本文复制引用
基金项目
海南省科学技术厅资助的科研项目(ZDYF2021SHFZ096)
出版年
2024
国家科技期刊平台
NSTL
万方数据