The role of CCN family proteins in diabetes nephropathy
Diabetes kidney disease(DKD)is a kind of kidney disease characterized by progressive renal tissue fibrosis.On the premise that diabetes is the cause of kidney damage and chronic kidney disease(CKD)caused by other reasons is excluded,type 1 and type 2 diabetes patients can be diagnosed with DKD if they have persistent albuminuria,or if the estimated glomerular filtra-tion rate has declined for more than 3 months,or if renal biopsy conforms to the pathological diagnosis of DKD.The cell communi-cation network(CCN)family of proteins is a group of intercellular matrix proteins involved in regulating important cellular patho-physiological changes such as growth,apoptosis,aging,autophagy,migration,differentiation,and inflammation.Recent studies have shown that the CCN family proteins are significantly upregulated in the DKD rat kidney model,suggesting that they play an important role in the epithelial-mesenchymal transition(EMT)of DKD renal tubular epithelial cells and the progression of renal in-terstitial fibrosis.This article reviews the role and mechanism of CCN family proteins in mediating renal injury in DKD,in order to explore potential therapeutic targets for DKD.
Cellular communication networkDiabetes kidney diseaseepithelial-mesenchymal transitionRenal fibrosis
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