Research progress of complement regulatory factor and neuromyelitis optica spectrum disorders
Neuromyelitis optic spectrum disease(NMOSD)is a rare acquired and heterogeneous neuro-ophthalmic crossover disease.It specifically occurs in the central nervous system such as the optic nerve and spinal cord,causing severe disability and blindness.Although the importance of complement in the pathogenesis of NMOSD has been confirmed,the key regulatory role of membrane complement regulatory factor in the pathogenesis of NMOSD is not fully understood.Discussing its physiological and pathological role in the pathogenesis of NMOSD may be one of the important reasons to explain the central pathogenesis of NMOSD.This review focuses on the recent research progress of complement regulatory factors CD46,CD55 and CD59 related to the pathogenesis of NMOSD,and attempts to analyze and review the current status and future development prospects of comple-ment regulatory factors in the pathogenesis of NMOSD.
国家科技期刊平台
NSTL
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