海南医学院学报2024,Vol.30Issue(17) :1346-1352.DOI:10.13210/j.cnki.jhmu.20240429.005

COVID-19相关肺纤维化的病因机制及治疗的研究进展

Research progress on the mechanism,and treatment of COVID-19 related pulmonary fibrosis

王梓源 李琪 黄娅 黄建鑫 周向东
海南医学院学报2024,Vol.30Issue(17) :1346-1352.DOI:10.13210/j.cnki.jhmu.20240429.005

COVID-19相关肺纤维化的病因机制及治疗的研究进展

Research progress on the mechanism,and treatment of COVID-19 related pulmonary fibrosis

王梓源 1李琪 2黄娅 1黄建鑫 1周向东2
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作者信息

  • 1. 海南医学院第一附属医院呼吸内科,海南 海口 570102
  • 2. 海南医学院第一附属医院呼吸内科,海南 海口 570102;海南省呼吸疾病中心,海南 海口 570100
  • 折叠

摘要

新型冠状病毒肺炎(COVID-19)是一种由SARS-CoV-2感染所引起的急性呼吸道传染性疾病.随着近期 COVID-19 疫情的常态化流行,COVID-19 患者的影像学及病理学研究表明,部分患者SARS-CoV-2感染后可出现肺纤维化改变,COVID-19相关肺纤维化正成为影响患者预后生存质量的重要影响因素,严重威胁患者的生命健康.目前,COVID-19相关肺纤维化的发病机制尚未明确,治疗方案多基于既往肺纤维化疾病的诊治经验,本文通过总结SARS-CoV-2感染后肺损伤及纤维化的发生机制和相关治疗方案,为临床的防治及干预提供一定参考.

Abstract

COVID-19 is an acute respiratory infectious disease caused by SARS-CoV-2 infection.With the recent normaliza-tion of the COVID-19 epidemic,imaging and pathological studies of COVID-19 patients have shown that some patients can devel-op pulmonary fibrotic changes after SARS-CoV-2 infection,and COVID-19-associated pulmonary fibrosis is becoming an impor-tant influencing factor affecting the quality of patients' prognostic survival,which is a serious threat to the life and health of pa-tients.At present,the pathogenesis of COVID-19-associated pulmonary fibrosis has not been clarified,and the treatment plan is mostly based on the previous experience in the diagnosis and treatment.In this paper,we summarize the mechanism of lung injury and fibrosis after SARS-CoV-2 infection and the related treatment plan,to provide a certain reference for the prevention,treat-ment and intervention of the clinic.

关键词

新型冠状病毒肺炎/肺纤维化/发病机制/抗纤维化治疗

Key words

COVID-19/Pulmonary fibrosis/Pathogenesis/Antifibrosis therapy

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基金项目

国家自然科学基金资助项目(82260001)

国家自然科学基金资助项目(82160012)

海南省重大科技专项(ZDKJ2021036)

海南省创新团队项目(820CXTD448)

海南省重点研发计划国际科技合作研究项目(ZDYF2020223)

海南省重点研发计划国际科技合作研究项目(GHYF2022011)

出版年

2024
海南医学院学报
海南医学院

海南医学院学报

CSTPCD北大核心
影响因子:1.068
ISSN:1007-1237
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