Research progress on the regulatory mechanisms of m6A methylation in the occurrence and development of lung cancer
N6-methyladenosine(m6A)is one of the most prevalent forms of RNA modification in eukaryotic cells,falling un-der the category of epigenetic modifications,and it plays a crucial role in the onset and development of various types of tumors.Lung cancer stands as one of the malignant tumors with the highest mortality rate globally,characterized by a complex pathogene-sis,difficulty in early diagnosis,and limited therapeutic options.m6A modifications play a significant role in lung cancer,with ab-normalities in the expression of related factors leading to dysregulation of m6A modifications,subsequently impacting the progres-sion of lung cancer.This phenomenon suggests that m6A modification-related factors may serve as potential targets for lung cancer therapy or as diagnostic biomarkers.Hence,this article provides a comprehensive review of the role of m6A modifications in the de-velopment and progression of lung cancer,exploring their relationship with the biological behaviors of lung cancer cells and the tu-mor microenvironment,and discussing the interactions between m6A modifications and lung cancer-related signaling pathways.This review offers valuable insights for a deeper understanding of the role of m6A methylation in the onset and development of lung cancer,holding significant implications for the development of novel diagnostic and therapeutic strategies.
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