铁死亡在非小细胞肺癌机制特性及免疫微环境中作用的研究进展
Research progress of ferroptosis in the mechanism and immune microenvironment of non-small cell lung cancer
郭晓阳 1曾凡 1郑楷 1李标2
作者信息
- 1. 海南医学院,海南 海口 571199
- 2. 海南医学院第二附属医院,海南 海口 570216;海南省医师协会胸外科医师分会,海南海口 571924
- 折叠
摘要
铁死亡(ferroptosis)是近年来新发现的、以氧化还原途径为特征的细胞死亡方式.它在机制特性以及调控代谢等方面都与以往的细胞凋亡、细胞坏死和自噬等经典途径不同.随着对非小细胞肺癌(NSCLC)肿瘤微环境和铁代谢异常的深入研究,铁死亡引起了学术界的广泛关注.本文重点介绍了铁死亡在NSCLC发展中的调控机制、铁死亡对NSCLC细胞生物学特性的影响以及铁死亡在免疫微环境中的作用,深入探讨铁死亡作为临床治疗靶点的可能性,为NSCLC治疗策略的发展提供新思路.
Abstract
Ferroptosis is a newly discovered cell death pattern characterized by pathway of reduction-oxidation in recent years.It is different from the classical pathways such as apoptosis,necrosis and autophagy in its mechanism and regulation of metabolism.With the in-depth study of tumor microenvironment and iron metabolism abnormalities in non-small cell lung cancer(NSCLC),ferroptosis has attracted extensive attention in the academic community.This paper focuses on the regulatory mechanism of ferrop-tosis in the development of NSCLC,the effects of ferroptosis on the biological characteristics of NSCLC cells,and the role of fer-roptosis in the immune microenvironment,aiming to further explore the possibility of ferroptosis as a clinical therapeutic target and provide new ideas for the development of therapeutic strategies for NSCLC.
关键词
铁死亡/非小细胞肺癌/肿瘤免疫/细胞生物学特性/调控机制Key words
Ferroptosis/Non-small cell lung cancer/Tumor immunity/Cell biological characteristics/Regulation mechanis引用本文复制引用
基金项目
2022年海南省自然科学基金项目(822RC843)
出版年
2024
国家科技期刊平台
NSTL
万方数据