Research progress on the biological role of extraoral sweet taste receptors
The sweet taste receptor(STR)is a critical member of type 1 taste receptors that senses sweetness and is activated by different types of saccharides and artificial sweeteners.Although it was originally discovered in oral taste buds,recent findings have demonstrated their expression in extraoral tissues such as the myocardium,kidneys,pancreas,gastrointestinal tract,respira-tory tract,and brain.They facilitate diverse biological functions,including the modulation of feeding activities,energy homeosta-sis,endocrine metabolism,endothelial permeability,immune defense,and cognitive function.In this review,the advancement in understanding the signaling pathways of STR and their biological roles in extraoral tissues was elucidated,aiming to provide a ref-erence for future research.
Sweet taste receptor(STR)Signaling pathwayBiological role
国家科技期刊平台
NSTL
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