The Role and Therapeutic Potential of CD39 in the Immune Microenvironment of Glioblastoma
Glioblastoma multiforme(GBM)is the most common malignant brain tumor in adults,which leads to poor progno-sis due to its high heterogeneity,rapid growth and intense aggressiveness.In recent years,the role of cell surface enzyme CD39 in the GBM tumor microenvironment has received widespread concern.CD39 produces the immunosuppressive molecule adenosine(ADO)by efficiently decomposing extracellular ATP and ADP,which significantly affects the anti-tumor immune response.This article reviewed the function of CD39 in regulating a variety of immune cells in GBM,such as MDSCs,TAMs,TILs,NKs and DCs,and discussed the therapeutic strategies for CD39,including the potential of inhibitor and antibody therapy,to provide new ideas for GBM therapy.This study provides a new perspective for the development of more effective GBM treatments and is ex-pected to improve patient outcomes.
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