Potential mechanisms and research progress of G protein-coupled receptor 124 in periodontitis
G protein-coupled receptor 124(GPR124)can promote the expression of VEGF,NLRP3 and PPARγ to partici-pate in the occurrence and development of periodontitis,and cause pathological changes such as gingival microcirculation deteriora-tion and inflammatory injury of endothelial cells.This article will summarize the biological characteristics of GPR124 and elaborate the possible relationship between GPR124 and NLRP3,VEGF,and PPARγ in the deterioration of periodontitis,so as to provide new treatment ideas for patients with periodontitis or periodontitis accompanied by systemic diseases.
G protein-coupled receptor 124PeriodontitisNLRP3Vascular endothelial growth factorPeroxisome prolifer-ator-activated receptors γ
万方数据
维普
