Research progress of targeting glutaminase to treat tissue fibrosis
Tissue fibrosis is one of the important causes of disability and mortality in various chronic diseases,and its preven-tion and treatment are also major challenges in the medical field.Myofibroblasts are the core involved in the progression of tissue fi-brosis.Glutaminolysis can provide energy for the activation and proliferation of myofibroblasts.Glutaminase is a key and initiating enzyme in the process of glutaminolysis and plays a crucial role in the realization of glutamine function.In this paper,the role of glutaminase in tissue fibrosis and related signaling pathways are introduced.In addition,the treatment strategies for tissue fibrosis targeting glutaminase are also analyzed.In conclusion,glutaminase is expected to be a key target for the treatment of tissue fibro-sis,and this paper aims to provide some reference for research on tissue fibrosis.
国家科技期刊平台
NSTL
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