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注射用紫杉醇(白蛋白结合型)致口干1例

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1例67岁女性乳腺恶性肿瘤患者使用AT方案(表柔吡星:120mgd1;多西他赛:120mgd1)行新辅助治疗一个周期后,因患者拒绝服用大量激素预防多西他赛的过敏反应,随将化疗药物多西他赛更换为注射用紫杉醇(白蛋白结合型,艾越)200mgd1,d8,化疗4个周期.患者每次在输注完注射用紫杉醇(白蛋白结合型,艾越)第二天出现口干的不适反应,通过适当的饮水并使用喷壶向口中喷水可明显缓解不适症状.考虑患者出现口干症状很可能与注射用紫杉醇(白蛋白结合型)有关.
A Case of Xerostomia Caused by Paclitaxel for Injection(Albumin Binding Type)
A 67 year old female patient with breast cancer received neoadjuvant therapy with the AT regimen(epirubicin:120 mg d1;docetaxel:120 mg d1)for one cycle.However,due to the patient's refusal to take a large a-mount of hormones to prevent allergic reactions to docetaxel,the chemotherapy drug docetaxel was replaced with pa-clitaxel(albumin bound Aiyue)200 mg d1,d8,and 5 cycles of chemotherapy.The patient experiences discomfort with dry mouth on the second day after each infusion of paclitaxel(albumin bound Aiyue).The discomfort can be significantly relieved by drinking appropriate water and using a watering can to spray water into the mouth.Considering that the patient's symptoms of dry mouth may be related to the injection of paclitaxel(albumin binding type).

Taxol for injection(albumin binding type)XerostomiaAdverse reactions

金彩丽、郭永福

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定西市人民医院药学部,甘肃定西 743000

注射用紫杉醇(白蛋白结合型) 口干 药物不良反应

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(1)
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