首页|干粉吸入剂辅料的研究进展

干粉吸入剂辅料的研究进展

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干粉吸入剂(DPI)是一种通过肺部给药的制剂,具有生物利用度高、起效快、无首过效应以及无污染等众多优点,在国内外已有多款产品上市销售.干粉吸入剂是吸入制剂的其中一种,属于化学高端制剂,有着巨大的市场潜力.同时其技术壁垒高,开发难度较大,已成为医药行业研究的热点和难点.本文就对干粉吸入剂的辅料研究进展进行归纳和总结,期望为干粉吸入制剂处方开发中辅料的选择提供参考.
Research Progress of Excipients of Dry Powder Inhalation
Dry powder inhalation(DPI)is a preparation that is administered through the lungs.It has many ad-vantages such as high bioavailability,fast onset of action,no first-pass effect,and no pollution.Many products have been marketed at home and abroad.Dry powder inhalation is one of the inhaler preparations,which belongs to the high-end chemical preparations and has huge market potential.At the same time,its high technical barriers and diffi-cult development have become a hot spot and difficulty in pharmaceutical industry research.This paper summarizes the research progress of excipients for Dry powder inhalation,hoping to provide a reference for the selection of excipi-ents in the formulation development of DPI.

Dry powder inhaltionExcipientLactoseLeucineMannitolMagnesium stearate

叶永浩、于希、肖颖、陈永奇

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珠海瑞思普利医药科技有限公司,广东珠海 519000

澳门科技大学医学院,中国澳门 999078

澳门科技大学中药质量研究国家重点实验室,中国澳门 999078

干粉吸入剂 辅料 乳糖 亮氨酸 甘露醇 硬脂酸镁

珠海市产学研珠港澳合作项目(2020)珠海市创新创业团队项目(2020)

ZH22017002200002PWC2120004000325

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(2)
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