Popular Science Intervention and Effect Evaluation of Drug Use in Osteo-porosis Patients
OBJECTIVE To compare the effects of popular science intervention on osteoporosis(OP)patients,and to form a popular science intervention method and resources aiming at promoting clinical efficacy.METHODS To formulate a scientific intervention program for OP patients.Clinical indicators such as MPR,bone mineral density,biochemical markers of bone turnover,bone specific alkaline phosphatase(BALP)and cross-linked C-terminal pep-tide of type I collagen(CTX-I),and incidence of fragile fracture were selected as evaluation basis.The effect of sci-entific intervention on OP was evaluated by comparing with control group.RESULTS The MPR value of the popu-lar science intervention group was(0.87±0.56),(0.75±0.32),(0.68±0.32)at 12,24 and 48 weeks after treatment,and the medication compliance was significantly higher than that of the control group(P<0.05);the BMD value and T value of the popular science intervention group were(0.738±0.081)g/cm2 and(-2.534±0.539),respectively,which were significantly higher than those of the control group(P<0.05);the BALP and β-CTX of the popular science intervention group were(21.082±8.112)μg·L-1 and(0.959±0.412)μg·L-1,(18.349±8.128)μg·L-1 and(0.741±0.409)μg·L-1,(16.368±9.011)μg·L-1 and(0.627±0.401)μg·L-1 at 12,24 and 48 weeks after treatment,respectively.The incidence of brittle fracture in the popular science intervention group was 5.3%,which was significantly lower than that in the control group(P<0.05).CONCLUSION Scientific intervention on medication for op patients can greatly improve their compliance with medication,effectively improve the effect of medication,and improve the quality of life of patients.
OsteoporosisPopular science intervention of drug useEffect evaluation
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