摘要
目的 比较对骨质疏松症(OP)患者进行用药科普干预的效果,形成以促进临床疗效为目标的科普干预方法和科普资源.方法 制定OP患者的用药科普干预方案,选择药物持有率(MPR)、骨密度(BMD)、骨转换生化标记物骨特异性碱性磷酸酶(BALP)和I型胶原交联c端肽(CTX-I)及脆性骨折发生率等临床指标作为评价依据,与对照组进行比较,评估科普干预对OP治疗的效果.结果 科普干预组MPR值在治疗后12 周、24 周、48 周内分别为(0.87±0.56)、(0.75±0.32)、(0.68±0.32),用药依从性明显高于对照组(P<0.05);科普干预组治疗后的BMD值和T值分别为(0.738±0.081)g/cm2 和(-2.534±0.539),较对照组明显升高(P<0.05);科普干预组患者BALP和β-CTX在治疗后12、24、48 周分别为(21.082±8.112)μg·L-1和(0.959±0.412)μg·L-1、(18.349±8.128)μg·L-1和(0.741±0.409)μg·L-1、(16.368±9.011)μg·L-1和(0.627±0.401)μg·L-1,较对照组降低的更为明显(P<0.05),科普干预组患者脆性骨折发生率降低为5.3%,较对照组明显降低(P<0.05).结论 通过对骨质疏松患者用药开展科普干预,可大大提高患者用药依从性,有效改善药物治疗效果,提高患者生活质量.
Abstract
OBJECTIVE To compare the effects of popular science intervention on osteoporosis(OP)patients,and to form a popular science intervention method and resources aiming at promoting clinical efficacy.METHODS To formulate a scientific intervention program for OP patients.Clinical indicators such as MPR,bone mineral density,biochemical markers of bone turnover,bone specific alkaline phosphatase(BALP)and cross-linked C-terminal pep-tide of type I collagen(CTX-I),and incidence of fragile fracture were selected as evaluation basis.The effect of sci-entific intervention on OP was evaluated by comparing with control group.RESULTS The MPR value of the popu-lar science intervention group was(0.87±0.56),(0.75±0.32),(0.68±0.32)at 12,24 and 48 weeks after treatment,and the medication compliance was significantly higher than that of the control group(P<0.05);the BMD value and T value of the popular science intervention group were(0.738±0.081)g/cm2 and(-2.534±0.539),respectively,which were significantly higher than those of the control group(P<0.05);the BALP and β-CTX of the popular science intervention group were(21.082±8.112)μg·L-1 and(0.959±0.412)μg·L-1,(18.349±8.128)μg·L-1 and(0.741±0.409)μg·L-1,(16.368±9.011)μg·L-1 and(0.627±0.401)μg·L-1 at 12,24 and 48 weeks after treatment,respectively.The incidence of brittle fracture in the popular science intervention group was 5.3%,which was significantly lower than that in the control group(P<0.05).CONCLUSION Scientific intervention on medication for op patients can greatly improve their compliance with medication,effectively improve the effect of medication,and improve the quality of life of patients.
基金项目
全国医药经济信息网科技传播创新工程重点项目(2017)(CMEI2017KP00205)
NETL
NSTL
万方数据