Fatal Hemoptysis in a Patient with Advanced Lung Squamous Cell Carci-noma Treated with Apatinib
OBJECTIVE To investigate the efficacy and safety of apatinib in patients with advanced lung squa-mous cell carcinoma,and to provide reference for rational application of apatinib in clinic.METHODS The clinical efficacy and safety of apatinib after chemotherapy combined with targeted therapy was in a patient with advanced lung squamous cell carcinoma.RESULTS The short-term curative effect of this patient was the reduction of tumor vol-ume and obvious effect,and the main adverse reaction was numbness in hands and feet.Although hand-foot syndrome appeared,the patient could tolerate it.Unfortunately,the patient died of massive hemoptysis,which may be caused by the large area of tumor necrosis and the erosion of bronchial artery rupture.CONCLUSION Apatinib could be cho-sen as one of the targeted therapy drugs for patients with advanced lung squamous cell carcinoma.However,physi-cians should focus on choosing suitable candidates,and the coagulation function of patients should be closely moni-tored when using apatinib.Furthermore,patients with the risk of bleeding should be used with caution to reduce the risk of fatal bleeding.in addition,the dosage of apatinib should be adjusted timely according to the patient's own con-dition to prevent fatal bleeding.
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