Mechanism of ShenLing BaiZhu Powder for Metabolic Associated Fatty Liver Disease Based on Network Pharmacology and Molecular Docking
OBJECTIVE To explore the potential mechanism of ShenLing BaiZhu powder in the treatment of metabolic associated fatty liver disease by using network pharmacology and molecular docking technolo-gy.METHODS The TCMSP database was used to collect the compound components of ShenLing BaiZhu powder and its target of action,and the GeneCards and Drugbank databases were used to collect the disease targets of meta-bolic associated fatty liver,and the key active components and core targets were screened with the help of Cytascape 3.9.1 software.Among them,the gene target of ShenLing Baizhu Powder-metabolic associated fatty liver was analyzed by protein interaction in STRING database and the GO function and KEGG pathway enrichment analysis in Metascape database.Finally,the molecular docking verification was carried out with AutoDock Vina 1.1.2 software.RESULTS The key active ingredients screened are quercetin,stigmasterol,kaempferol,luteolin,beta-sitosterol,7-Methoxy-2-methyl isoflavone and naringenin.The core targets are AKT1,TNF,IL6,TP53,VEGFA,IL1B,CASP3,ESR1,MAPK3,PTGS2.The potential targets are mainly concentrated in p53 signaling pathway,TNF signaling pathway,IL-17 signaling pathway,Th17 cell differentiation.Molecular docking results showed that the binding force was good.CONCLUSION The ShenLing BaiZhu powder has the characteristics of multi-component,multi-target and multi-path in the treatment of metabolic associated fatty liver disease.
万方数据
维普
