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破壁灵芝孢子粉对小鼠免疫功能的影响

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目的 研究破壁灵芝孢子粉对小鼠免疫功能的影响.方法 ICR雄性小鼠随机分为4 大组,高中低(0.99、0.33、0.165 g·kg-1)3 个给药组和空白对照组,小鼠30 天灌胃给药后,对小鼠各项免疫学指标检测.结果 与对照组比较,破壁灵芝孢子粉高、中剂量组在2,4 二硝基氟苯(DNFB)诱导的迟发型变态反应中具有显著性差异(P<0.05、P<0.01);同时高剂量组能促进小鼠NK细胞活性.结论 破壁灵芝孢子粉可增强DNFB诱导的迟发型变态反应,对小鼠细胞免疫功能具有一定增强效果;同时能促进NK细胞活性,有助于增强小鼠免疫吞噬功能.
Effects of the Powder of Broken Ganoderma Spores on Immunity of Mice
OBJECTIVE To study the effects of the powder of broken Ganoderma spores on immune functions of mice.METHODS ICR male mice were randomly divided into 4 groups,three treatment groups(0.165,0.33,0.99 g·kg-1)and a blank control group.After 30 days of intragastric administration,the mice were tested for various im-munological indicators.RESULTS Compared with Control group,there were significant differences in the delayed type allergic reactions induced by 2,4-dinitrofluorobenzene(DNFB)(P<0.05,P<0.01)between the high and me-dium dose groups;Meanwhile,the high dose group could promote the activity of NK cells.CONCLUSION Gano-derma lucidum spore powder can enhance DNFB-induced delayed allergic reaction,and has an effect on the cellalar immune function of mice.At the sametime,it can promote the activity of NK cells and help enhance the immune phagocytosis function of mice.

The powder of broken GanodermaImmunityHumoral immunityCellular immunity

张熠、刘用国、许娇红、杨秀静、王江融、张红雷、李鸣

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福建省食品药品质量检验研究院,福建福州 350001

破壁灵芝孢子粉 免疫功能 体液免疫 细胞免疫

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(3)
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