Efficacy and Safety of Oral Dapagliflozin in the Treatment of Type 2 Dia-betes Mellitus Complicated with Asymptomatic Hyperuricemia
OBJECTIVE To investigate the efficacy and safety of dapagliflozin in the treatment of type 2 diabe-tes with hyperuricemia.METHODS 122 patients with type 2 diabetes complicated with asymptomatic hyperurice-mia were randomly divided into control group(n =60)and observation group(n =62).62 patients in the observa-tion group were treated with oral metformin 1 tablet tid combined with Dapagliflozin 1 tablet qd.Patients in both groups were treated for 12 weeks.The fasting blood glucose level,2 h blood glucose level,HbA1c,serum uric acid(BUA),serum creatinine(Scr),blood urea nitrogen(BUN)and adverse reactions were compared between the two groups before and after treatment.RESULTS The fasting blood glucose level,2 h blood glucose level,HbAlc,BUA and BUN in the observation group were significantly decreased,but there was no significant difference in Scr and ad-verse reactions between the two groups.CONCLUSION Oral administration of Dapagliflozin tablets in the treat-ment of type 2 diabetes with asymptomatic hyperuricemia can effectively control blood glucose,reduce the level of BUA and delay related complications,which has certain value of clinical application.
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