Use of Monte Carlo Simulation to Evaluate and Optimize the Dosage Reg-imen of Amikacin in Patients with Sepsis
OBJECTIVE According to the PK/PD theory of antibiotics,Monte Carlo simulation was used to e-valuate and optimize the administration regimen of amikacin in patients with sepsis.METHODS The pharmacoki-netic data of amikacin published at home and abroad were collected and the MIC distribution data of amikacin against Gram-negative bacilli in our hospital were extracted.The Cristal Ball software was used to simulate the probability of goal attainment(PTA)and cumulative response fraction(CRF)in 10000 patients.RESULTS The recommended dose of amikacin for sepsis patients failed to achieve satisfactory antibacterial activity.CONCLUSION Monte Carlo simulation method combines pharmacokinetic parameters with pharmacodynamic data,which not only considers the difference of drug disposal among different individuals,but also considers the difference of drug resistance of patho-genic bacteria.The recommended dosage regimen can better achieve the goal of individualized administration,improve the clinical treatment effect and reduce bacterial resistance.
万方数据
维普
