Non-alcoholic fatty liver disease(NAFLD)has become the most common chronic liver disease world-wide and is closely related to oxidative stress.Disorders of lipid metabolism lead to the accumulation of lipids in the liver,which in turn causes mitochondria,endoplasmic reticulum and other oxidases to produce large amounts of Reac-tive oxygen species(ROS).Increased ROS production can cause altered insulin sensitivity and altered expression and activity of key enzymes in lipid metabolism,but the role of oxidative stress on the pathogenesis of NAFLD is un-clear.Based on the above viewpoints,this article reviews the mechanisms that may lead to the overproduction of ROS and the underlying mechanisms by which ROS drives the progression of NAFLD.
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