Effects of Edaravone on the Renin-Angiotensin System in Microglia Acti-vated by Oxygen Glucose Deprivation
OBJECTIVE To observe the expression of renin-angiotensin system(RAS)in BV-2 cells activated by oxygen-glucose deprivation(OGD)and the effect of edaravone on it.METHODS BV-2 cells cultured in vitro were randomly divided into Control group,OGD group and edaravone pretreatment+OGD group.The expression lev-els of RAS-related proteins(ATO,ACE and AT1)were detected by Western Blot and immunofluorescence stai-ning.RESULTS Compared with the Control group,the expression levels of ATO,ACE,and AT1 were significantly increased in the OGD group,while those were significantly reduced after edaravone intervention.RESULTS were statistically significant.CONCLUSION Edaravone can inhibit the expression of RAS system-related molecules in OGD-induced BV-2 cells.
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