OBJECTIVE To investigate the distribution and drug resistance of Escherichia coli in clinical sam-ples in recent 5 years,and to provide reference for rational selection of antibiotics in clinic.METHODS VITEK-COMPCAT bacterial identification and drug sensitivity analyzer was used to perform bacterial isolation and identifica-tion and drug sensitivity test on 9095 microbial samples(positive samples)submitted by clinical departments of the hospital from January 2018 to December 2022,and extended-spectrum β-lactamases(ESBLs)were detec-ted.Statistical analysis was performed in combination with relevant clinical information.RESULTS A total of 2073 strains of Escherichia coli were detected in all specimens,and the detection rate of Escherichia coli was 22.79%(2073/9095).A total of 701 strains of Escherichia coli produced ESBLs,and the enzyme production rate was 33.80%(701/2073).Among the submitted specimens,the highest proportion of Escherichia coli was detected in u-rine specimens(34.15%,708/2073).Among the clinical departments submitted for inspection,the highest propor-tion of Escherichia coli was 32.66%(677/2073)in gastrointestinal surgery.The sensitivity rates of meropenem,tige-cycline,amikacin,cefotetan and piperacillin/tazobactam were 100.00%,100.00%,98.87%,98.11%and 96.44%,respectively.CONCLUSION The detection rate of Escherichia coli increased first and then decreased steadily in the past five years.The proportion of Escherichia coli producing ESBLs showed a downward trend.Commonly used antibiotics maintained a high sensitivity rate to Escherichia coli.
维普
万方数据
