OBJECTIVE To investigate the efficacy and safety of anti-vascular osmotic factor drugs in the treat-ment of diabetic retinopathy.METHODS Clinical data of 72 patients with diabetic retinopathy in our hospital from October 2021 to May 2022 were retrospectively collected and divided into two groups according to different treatment methods:Group A(anti-vascular permeability factor drug therapy combined with laser group)and group B(laser group),with 36 cases in each group.The clinical indicators,quality of life scores and the incidence of complications within 3 months after treatment were compared between the two groups.RESULTS The clinical indexes,quality of life score and complication rate of group A after treatment were significantly better than those of group B,P<0.05.CONCLUSION The use of anti-vascular osmotic factor drugs can significantly improve the clinical diagnosis and treatment effect of diabetic retinopathy patients,high safety,suitable for promotion.