Analysis of the Adverse Drug Reactions for Brivaracetam Based on Open FDA
OBJECTIVE To explore the adverse drug reactions of brivaracetam,evaluate the adverse reactions after marketing,and provide a reference for the clinical use of the drug.METHODS The adverse event reports of brivaracetam collected in the US FDA Adverse Event Reporting System(FAERS)from February 18,2016 to June 30,2023.RESULTS A total of 3955 ADR reports were received from brivaracetam,with the United States reported the most,with serious adverse reactions accounting for more than 80%,and off-label drugs accounting for more than 14%of adverse reactions.Unearthed adverse reactions not mentioned in the instructions,such as memory impair-ment,cognitive disorder,diarrhea,diplopia,alopecia hyponatremia,etc.CONCLUSION When applying brivarace-tam,it is necessary to be vigilant against off-label use,pay attention to adverse reactions outside the label,and carry out necessary pharmaceutical monitoring.
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