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竹节参醇提物化学成分研究

Study on the Chemical Composition of Ethanol Extracts of Panax japonicus

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目的 研究五加科植物竹节参(Panax japonicus C.A.Mey.)干燥根茎的化学成分.方法 竹节参醇提物经柱色谱与制备液相等多种方法进行分离纯化,根据化合物的理化性质、核磁共振图谱及质谱数据对其进行结构解析与鉴定.结果 从竹节参中共分离鉴定出了11 种皂苷类化学成分,分别为:人参皂苷Re(1)、人参皂苷Rg1(2)、竹节参皂苷Ⅴ(3)、24-(R)珠子参苷(4)、竹节参皂苷Ⅳa(5)、竹节参皂苷Ⅳa甲酯(6)、竹节参皂苷Ⅳ(7)、竹节参皂苷Ⅳ甲酯(8)、竹节参皂苷Ⅰ(9)、金盏花苷E(10)、竹节参皂苷Ⅳa乙酯(11).结论 化合物4、10、11 位首次从竹节参中分离得到.
OBJECTIVE This study aimed to comprehensively analyze the chemical constituents present in the dried rhizomes of Panax japonicus.METHODS The Ethanol Extracts was separated and purified by column chro-matography and liquid phase preparation and the isolated compounds were identified and their structures were eluci-dated through analysis of their physicochemical properties,nuclear magnetic resonance(NMR)spectroscopy,and mass spectrometry(MS)data.RESULTS A total of eleven saponin compounds were successfully isolated and iden-tified from the dried rhizomes of Panax japonicus.The structures and names of these compounds are as follows:Gin-senoside Re(1),Ginsenoside Rg1(2),Chikusetsusaponin V(3),24-(R)-Majoroside R1(4),Chikusetsusaponin Ⅳa(5),Chikusetsusaponin Ⅳa Methyl Ester(6),Chikusetsusaponin Ⅳ(7),Chikusetsusaponin Ⅳ Methyl Ester(8),Chikusetsusaponin Ⅰ(9),Calenduloside E(10),Chikusetsu-saponin IVa Ethyl Ester(11).CONCLUSION Com-pounds 4,10,and 11 were isolated for the first time from Panax Japonicus.

Panax japonicasChemical compoundsSaponinIsolationIdentification

李道文、邓庆华、贾俊、戚进

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中国药科大学中药学院,江苏南京 211198

重庆医药高等专科学校,重庆 401331

重庆市药物制剂工程技术中心,重庆 401331

竹节参 化学成分 皂苷 分离 鉴定

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(5)