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竹节参醇提物化学成分研究

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目的 研究五加科植物竹节参(Panax japonicus C。A。Mey。)干燥根茎的化学成分。方法 竹节参醇提物经柱色谱与制备液相等多种方法进行分离纯化,根据化合物的理化性质、核磁共振图谱及质谱数据对其进行结构解析与鉴定。结果 从竹节参中共分离鉴定出了11 种皂苷类化学成分,分别为:人参皂苷Re(1)、人参皂苷Rg1(2)、竹节参皂苷Ⅴ(3)、24-(R)珠子参苷(4)、竹节参皂苷Ⅳa(5)、竹节参皂苷Ⅳa甲酯(6)、竹节参皂苷Ⅳ(7)、竹节参皂苷Ⅳ甲酯(8)、竹节参皂苷Ⅰ(9)、金盏花苷E(10)、竹节参皂苷Ⅳa乙酯(11)。结论 化合物4、10、11 位首次从竹节参中分离得到。
Study on the Chemical Composition of Ethanol Extracts of Panax japonicus
OBJECTIVE This study aimed to comprehensively analyze the chemical constituents present in the dried rhizomes of Panax japonicus.METHODS The Ethanol Extracts was separated and purified by column chro-matography and liquid phase preparation and the isolated compounds were identified and their structures were eluci-dated through analysis of their physicochemical properties,nuclear magnetic resonance(NMR)spectroscopy,and mass spectrometry(MS)data.RESULTS A total of eleven saponin compounds were successfully isolated and iden-tified from the dried rhizomes of Panax japonicus.The structures and names of these compounds are as follows:Gin-senoside Re(1),Ginsenoside Rg1(2),Chikusetsusaponin V(3),24-(R)-Majoroside R1(4),Chikusetsusaponin Ⅳa(5),Chikusetsusaponin Ⅳa Methyl Ester(6),Chikusetsusaponin Ⅳ(7),Chikusetsusaponin Ⅳ Methyl Ester(8),Chikusetsusaponin Ⅰ(9),Calenduloside E(10),Chikusetsu-saponin IVa Ethyl Ester(11).CONCLUSION Com-pounds 4,10,and 11 were isolated for the first time from Panax Japonicus.

Panax japonicasChemical compoundsSaponinIsolationIdentification

李道文、邓庆华、贾俊、戚进

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中国药科大学中药学院,江苏南京 211198

重庆医药高等专科学校,重庆 401331

重庆市药物制剂工程技术中心,重庆 401331

竹节参 化学成分 皂苷 分离 鉴定

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(5)