Research on the Correlation between CYP3A4 and CYP3A5 Gene Poly-morphism and the Efficacy and Adverse Reactions of Paclitaxel
OBJECTIVE To investigate the association between CYP3 A4 and CYP3 A5 gene polymorphism and the efficacy and adverse reactions of paclitaxel in patients with tumor.METHODS Sixty-seven patients who re-ceived paclitaxel chemotherapy from February 2016 to February 2020 were selected as experimental subjects,the CYP3 A4∗1G and CYP3 A5∗3 genotypes were detected,and the patients were divided into wild type group and mu-tant group.After 2 cycles,the efficacy and adverse drug reactions were evaluated,and the correlation between the effi-cacy and adverse drug reactions of patients and the polymorphism of CYP3 A4∗1G and CYP3A5∗3 gene was ana-lyzed.RESULTS Among 67 tumor patients,there was no significant difference between wild type group and mutant group of CYP3 A4∗1G and CYP3 A5∗3 in efficacy and adverse reactions(P>0.05).CONCLUSION CYP3 A4∗1G and CYP3 A5∗3 gene polymorphisms were irrelative with the efficacy and adverse reactions of paclitaxel.
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