Mechanism of HuoXue Powder in the Treatment of Fracture Based on Network Pharmacology and Molecular Docking
OBJECTIVE To elucidate the effective components and mechanism of HuoXue Powder in the treat-ment of fracture by network pharmacology.METHODS The main components of HuoXue Powder were obtained and screened by TCMSP database and literature search.Pubchem and Swiss Target Prediction database were used to obtain the Target of components.GeneCards and OMIM databases were searched to obtain the targets related to frac-ture and blood stasis.Venny 2.1 online analysis tool was used to construct Venn diagram to obtain the intersection targets of drugs and diseases.The String platform was used to conduct PPI protein network interaction for the intersec-tion targets,and the network diagram was drawn.Cytoscape 3.8.2 was used to draw the network diagram of"herbs-components".Metascape was used to perform GO function analysis and KEGG pathway enrichment analysis for inter-section targets.Finally,MOE software was used to dock the main active components with the core target.RESULTS HuoXue Powder in the treatment of fracture involves a variety of flavonoids in the compound,and the therapeutic mechanism may be related to the regulation of HIF-1,VEGF,AMPK and other signaling pathways.CONCLUSION This study elucidated the main active components and mechanism of HuoXue Powder in the treatment of fracture,and provided theoretical basis for clinical application.
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维普
