首页|61例非离子型碘造影剂不良反应的回顾性分析

61例非离子型碘造影剂不良反应的回顾性分析

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目的 探讨心血管病专科医院非离子型碘造影剂不良反应(ADR)的特点及相关规律.方法 将某心血管病专科医院2018年9月至2021年4月61例非离子型碘造影剂相关药品不良反应(ADR)报告中患者年龄、性别、ADR类型、用药情况、临床表现等进行分类统计、分析,并将结果与文献报道进行对比.结果 该院不良反应发生率为0.267%,碘海醇注射液0.176%,碘普罗胺注射液0.667%,碘帕醇注射液0.230%,碘克沙醇注射液0.354%.严重不良反应3例,发生率0.0131%.48例急性ADR,构成比78.69%,迟发性ADR13例,构成比21.31%,无晚发性ADR.结论 该心血管病专科医院非离子型碘造影剂ADR发生率低于文献报道,严重ADR发生率与国外报道的一致,迟发性ADR发生率低于大多数既往研究报道.
Retrospective Analysis of 61 Cases of Adverse Reactions of Nonionic Iodide Contrast Agents
OBJECTIVE To investigate the characteristics and related rules of adverse reactions(ADRs)of non-ionic iodide contrast agents in cardiovascular hospitals.METHODS 61 cases of nonionic contrast media-relat-ed adverse drug reactions(ADRs)reported in a cardiovascular hospital from September 2018 to April 2021 were classified and analyzed by age,gender,ADR type,drug use and clinical manifestations,and the results were compared with literature reports.RESULTS The incidence of adverse reactions in the hospital was 0.267%,0.176%,0.667%,0.230%and 0.354%for iodoxanol injection.There were 3 serious adverse reactions(0.0131%).There were 48 acute ADRs(78.69%),13 delayed ADRS(21.31%),and no late ADRs.CONCLUSION The inci-dence of ADR of non-ionic iodide contrast agents in this cardiovascular hospital is lower than that reported in the lit-erature,the incidence of serious ADR is consistent with that reported abroad,and the incidence of delayed ADR is lower than that reported in most previous studies.

Nonionic iodine contrast agentAdverse drug reactionsRetrospective analysisCardiovascular hospital

莫小凤、徐文秀

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云南省阜外心血管病医院,云南 昆明 650011

非离子型碘造影剂 药物不良反应 回顾分析 心血管病专科医院

云南省教育厅科学研究基金项目

2024J0386

2024

海峡药学
中国药学会福建分会

海峡药学

影响因子:0.643
ISSN:1006-3765
年,卷(期):2024.36(8)