Exploring XueFu ZhuYu Decoction from the Perspective of"Prescription Syndrome and Disease Location"Based on Data Mining
OBJECTIVE To explore the scientific connotation of"Xuefu"in Wang Qingren through data min-ing and bioinformatics technology,and to deeply explore the clinical application law of XueFu ZhuYu Decoction,which is conducive to expanding the clinical application scope of XueFu ZhuYu Decoction.METHODS The XueFu ZhuYu Decoction was searched through the National Knowledge Infrastructure of China(www.cnki.net,CNKI),Wanfang Data(www.wanfangdata.com.cn,Wanfang Data),Weipu.com(www.cqvip.com,VIP)and China Bio-medical Literature Service System(www.sinomed.ac.cn,CBMdisc),and the frequency analysis and cluster analysis were performed by using TCMISS(V2.5)and Excel.Using network pharmacology technology,the target of 11 drugs of XueFu ZhuYu Decoction was downloaded from HERB database.The clusterProfiler package of R software was used for disease(DO)enrichment analysis.RESULTS A total of 107 medical records containing XueFu ZhuYu Decoc-tion were screened,involving 183 kinds of auxiliary Chinese medicines,and the most frequently used Chinese medi-cines were Astragalus membranaceus,Paeonia lactiflora,Salvia miltiorrhiza and Radix Curcumae.Most of the drugs are flat,warm and slightly cold;The medicine tastes bitter,pungent and sweet;Meridian tropism mostly belongs to liv-er,heart and spleen meridians.Three core prescriptionswere obtained by using the"new prescription analysis"func-tion of TCMISS(V2.5)software.Through the disease enrichment analysis,it is concluded that the diseases concen-trated in cardiovascular,respiratory and urinary systems are consistent with the speculation that the blood house is lo-cated in the chest.CONCLUSION XueFu ZhuYu Decoction is a common prescription for promoting blood circula-tion,removing blood stasis and regulating qi and blood,which embodies the guiding ideology of"treating different diseases at the same time"in traditional Chinese medicine.
NETL
NSTL
万方数据
