Distribution and Drug Sensitivity Analysis of Pathogen in Urinary Culture of Patients in Urology Department of One Hospital from 2020 to 2022
OBJECTIVE To analyze the pathogen distribution and drug sensitivity of urinary culture in patients of urology department in Pingshan District People's Hospital of Shenzhen in recent 3 years,and to provide reference for clinical rational antibiotic selection and optimization of treatment.METHODS From 2020 to 2022,non-dupli-cate pathogen from urine culture of urological patients in our hospital and the results of drug sensitivity test were col-lected.The positive rate of urine culture,the distribution characteristics and changes of pathogen and the changes of drug resistance were retrospectively analyzed.RESULTS Among 10163 samples,974 strains of non-repeated patho-gens were detected,with the detection rate of 9.58％.Among the 974 specimens,763 strains of Gram-negative bacte-ria accounted for 78.34％;171 strains of Gram-positive bacteria accounted for 17.56％;40 strains of fungi accounted for 4.11％.The top three gram-negative bacteria were Escherichia coli(60.47％),Proteus Mirabilis(6.67％)and Klebsiella pneumoniae(4.72％).The gram-positive bacteria were mainly Enterococcus faecalis(6.16％).The drug sensitivity test showed that the drug resistance rates of Escherichia coli to ampicillin,cotrimoxazole,ceftriaxone,cipro-floxacin and levofloxacin increased year by year,and the drug resistance rates were all over 30％in 2022.The sensi-tivity rate of Escherichia coli to piperacillin/tazobactam,cefepime,cefotetan,furantoin,amicacin and tobramycin was high,and the drug resistance rates were all lower than 10％.No carbapenems resistant Escherichia coli was detec-ted.The drug resistance rate of Enterococcus faecalis to tetracycline and erythromycin was high(both＞70％),and the resistance rate to erythromycin showed an increasing trend year by year.The drug sensitivity rate of Enterococcus faecalis to ampicillin,penicillin and vancomycin was high,and the drug resistance rates were all lower than 20％.No Enterococcus faecalis resistant to furantoin,linezol id and tigacycline were detected.CONCLUSION Escherichia coli is still the main pathogen in urinary culture of patients in urology department of our hospital.Rational antimicrobial drugs should be selected according to the drug resistance situation in recent years,the patient's clinical manifesta-tions,previous medication use,and the characteristics of antibiotic pharmacokinetics.rational selection of antibiotics.Then,according to the results of drug sensitivity test,combined with the therapeutic effect of empirical drug use,the administration plan was adjusted to improve the therapeutic efficacy and reduce adverse reactions and the generation of drug-resistant bacteria.
Urology departmentUrine cultureDrug sensitivity analysisAntibacterial drugRational administration of drugs
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