The Development of Liver Toxicity as well as the Abnormal Lipid Metabo-lism after Therapy with Prednisone and Vincristine
OBJECTIVE To investigate the risk factors for the development of liver toxicity as well as the ab-normal lipid metabolism after therapy with prednisone and vincristine.METHODS Adverse event associated with cholesterol and transaminases levels was classified and graded by Common Terminology Criteria for Adverse Events(CTCAE)Version 6.0.We obtained the adverse event reports and medication error reports using FDA Adverse E-vent Reporting System(FAERS).Multivariate Logistic regression was performed to determine the association between vincristine/prednisone and liver toxicity as well as the abnormal lipid metabolism.RESULTS Combination of vin-cristine and prednisone had a 2-fold increased risk of liver injury(OR=2.109,P=0.000)in children.Compared with prednisone,vincristine had a lower risk of abnormal lipid metabolism(OR=0.347,P=0.000).CONCLU-SION When vincristine is used in combination with prednisone,children may experience serious liver injury.
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