Retrospective Evaluation of Iron Sucrose Accelerated Regimen in the Treatment of Iron Deficiency Anemia
OBJECTIVE To evaluate the efficacy and safety of an accelerated iron sucrose dosing regimen for the treatment of iron deficiency anemia secondary to various etiologies.METHODS A retrospective analysis of medical records was performed on hospitalized patients who received iron sucrose(IS)supplementation between Jan-uary 1,2021 and June 30,2022 at a tertiary hospital.Safety was evaluated by reviewing medical records for any ad-verse reactions during IS infusion and parameters of liver function,renal function and serum phosphorus tests before and after infusion.Efficacy was assessed by examining the absolute reticulocyte count,hemoglobin,and iron parame-ters before and after infusion.RESULTS A total of 59 patients were enrolled during the study period,with 24 in the accelerated group and 35 in the conventional group.Significant increases in hemoglobin(Hb)levels were observed in both groups after iron supplementation compared to pre-treatment values(P＜0.001).There was no statistical difference in Hb levels between the two groups post-treatment[(89.38±12.85)g·L-1 in the accelerated group;(93.46±11.79)g·L-1 in the conventional group,P=0.213].Although the incidence of hypophosphatemia was higher in both groups,no clinical symptoms or other adverse reactions were reported.CONCLUSION Intensive iron supplementation is both safe and effective in managing multi-cause iron deficiency anemia,markedly elevating hemo-globin levels.Moreover,it exhibits a significant advantage in abbreviating hospitalization duration.
Iron sucroseIron deficiency anemiaAcceleration regimenRetrospective evaluation
万方数据
维普
