OBJECTIVE The extraction process of ChuanXiang JieYu Drink,which could provide a reference for the further development of ChuanXiang JieYu Drink,was optimised by determining the weights of the indica-tors.METHODS The indicators included ligustrolactone A,neohesperidin,atractylenolide Ⅲ and paste yield was used to score.And the parameters of ChuanXiang JieYu Drink were optimized by combining with the results of orthog-onal experiments.RESULTS The results showed good linearity(R=0.9945-0.9956)within 80-10000 ng·mL-1,80-10000 ng·mL-1 and 40-5000 ng·mL-1 for ligustrolactone A,Neohesperidin and atractylenolide Ⅲ,re-spectively.And the optimal extraction process conditions,which was determined by comprehensive evaluation accord-ing to the weighting coefficients,were as follows:add 6 times the amount of water with the prescribed herbs,decoct and extract for 3 times and each for 1.5 h.CONCLUSION The comprehensive score is reasonable,and it con-formed to the overall concept of Chinese medicine treatment.The process obtained by the preferred method was sta-ble,feasible and reproducible,and it could provide scientific basis for the standard of preparation process.
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