OBJECTIVE To analyze the characteristics and occurrence rules of adverse drug reactions(ADRs)of new antineoplastic drugs reported in our hospital,and to provide reference for ADR monitoring and rational drug use.METHODS A total of 95 cases of ADR of new anti-tumor drugs reported by our hospital from January 2020 to December 2023 were collected,and the basic information of patients,report type,occurrence time,route of adminis-tration,drugs involved,ADR involvement system,and prognosis were analyzed.RESULTS Among the 95 ADRs,the male-to-female ratio was 1∶083;and more than 80％of the ≥ were 50 years old;and the route of administration was intravenous infusion.ADRs involved 28 drugs,with 60 new and severe ADRs(63.16％)prog;rammed death protein 1(PD-1)inhibitors accounted for the highest proportion(31 cases,32.63％);and camrelizumab having the largest number(11 cases);ADR could involve multiple systems,and skin and its appendages were the most common(32 ca-ses,33.68％).CONCLUSION Clinical attention should be paid to the monitoring of ADR of new anti-tumor drugs,pay attention to the new and severe ADR of such drugs,strengthen the drug education of patients,and ensure the safety and sustainability of treatment.
关键词
新型抗肿瘤药物/药品不良反应/合理用药/药物警戒
Key words
New antineoplastic drugs/Adverse drug reactions/Rational use of drugs/Pharmacovigilance
维普
万方数据