Clinicopathologic Significance of Expression of SLeX and CK19 in Papillary Thyroid Carcinoma
Objective To investigate the clinicopathologic significance of SLeX and CK19 expression in papillary thyroid carcinoma(PTC).Methods Immunohistochemical Eli VisionTM plus two-step method was used to detect the expression of SLeX and CK19 in 120 pieces of primary PTC tissue who underwent resection and 30 pieces of adjacent carcinoma tissue.The relationship between the expression of SLeX and CK19 and the clinicopathological parameters including patient age,TI-RADS classification,TNM stag-ing,carcinomatous infiltration,lymph node metastasis(LNM)were analyzed by SPSS 22.0.Results In pieces of primary PTC tissue and pieces of adjacent carcinoma tissue,the positive rates of SLeX were 67.5％(81/120)and 6.7％(2/30),CK19 were 87.5％(105/120)and 10.0％(3/30),respectively,with statistically significant differences(P＜0.05).In the groups with patients aged＜45 years versus 45 years,the SLeX positive rates were 63.2％(48/76)and 75.0％(33/44),and the CK19 positive rates were 88.2％(67/76)and 86.4％(38/44),respectively,with no statistically significant differences between the two groups(P＞0.05).In the groups of TI-RADS(class 4 and 5)versus class 6,the SLeX positive rates were 62.1％(59/95)and 88.0％(22/25),respectively,and the differences between the two groups were statistically significant(P＜0.05).The CK19 positive rates were 85.3％(81/95)and 96.0％(24/25),respectively,with no statistically significant differences between the two groups(P＞0.05).In the groups of TNM(stage T1 and T2)versus stage T3,the SLeX positive rates were 58.2％(46/79)and 85.4％(35/41),and the CK19 positive rates were 82.3％(65/79)and 97.6％(40/41),respectively.In the groups with versus without carcinomatous infiltration,the SLeX positive rates were 79.2％(57/72)and 50.0％(24/48),and the CK19 positive rates were 94.4％(68/72)and 77.1％(37/48),respectively.In the groups with versus without LNM,the SLeX positive rates were 79.4％(54/68)and 51.9％(27/52),and the CK19 positive rates were 95.6％(65/68)and 76.9％(40/52),respectively,and the differences between the three above groups were statistically significant(P＜0.05).The copositive and conegative expression rates of SLeX and CK19 in 120 pieces of primary PTC tissue were 65.8％(79/120)and 10.8％(13/120),respectively,with a positive correlation(r=0.40,P＜0.05).Conclusion High expression of SLeX and CK19 in PTC may predict late tumor stage,more aggressive in-vasion and being more prone to LNM.
万方数据
维普
