Diagnostic Value of Serum PSA Levels Combined with MRI Parameters in Elderly Prostate Benign and Malignant Lesions
Objective To investigate the diagnostic value of serum PSA level and MRI-related parame-ters in benign and malignant prostate lesions in the elderly.Methods A total of 90 elderly patients with prostate cancer as the observation group,and 90 elderly patients with benign prostatic hyperplasia as the control group were examined by MR diffusion-weighted imaging,and the corresponding apparent diffusion coefficient(ADC)values were measured.The ADCmean and relative ADC(rADCmean)were calculat-ed.Serum PSA level was detected by enzyme-linked immunosorbent assay.The demographic data,phys-ical examination data,family history,personal history and clinical data of the patients were collected.Univariate and multivariate Logistic regression models were used to analyze the independent influencing factors affecting the diagnosis of benign and malignant prostates.The receiver operating characteristic curve was used to evaluate the diagnostic efficacy of different prediction models for prostate cancer.Re-sults There were significant differences in serum PSA level,ADCmean and rADCmean between the two groups(P＜0.05).Serum PSA level,ADCmean and rADCmean were independent influencing factors of prostate malignant tumors in the elderly.The AUC of serum PSA was 0.848(0.786～0.910),the AUC of ADCmean was 0.747(0.676～0.817),the AUC of rADCmean was 0.788(0.721～0.854),the AUC of serum PSA combined with ADCmean and rADCmean was 0.929(0.893～0.966).Conclusion Serum PSA combined with MRI-related parameters can significantly improve the diagnostic efficacy of benign and malignant prostate lesions in the elderly,and has important reference value for early clinical differentiation of benign and malignant prostate tumors.
Serum PSAApparent diffusion coefficientRelative mean apparent diffusion coefficientProstate benign and malignant lesionsElderly
万方数据
维普
