Clinical Efficacy of Preoperative Ranibizumab Injection Combined with Vitrectomy on Diabetic Retinopathy with Neovascular Glaucoma
Objective To investigate the clinical efficacy of preoperative ranibizumab injection com-bined with vitrectomy in the treatment of diabetic retinopathy(DR)with neovascular glaucoma(NVG).Methods A total of 80 patients with DR and NVG were selected and divided into control group and study group according to the random number table method,with 40 cases in each group.The control group was treated with conventional vitrectomy,and the study group was injected with ranibizumab before vitrecto-my.The success rate of operation,intraocular pressure,visual acuity,VEGF and IGF-1 levels were ob-served in the two groups.Results The success rate of operation in the study group was higher than that in the control group(P＜0.05).After 3 months of treatment,the levels of VEGF and IGF-1 in the two groups were decreased(P＜0.05),and those in the study group were lower than those in the control group(P＜0.05).The levels of intraocular pressure and visual acuity were improved(P＜0.05),and the improvement of the study group was better than that of the control group(P＜0.05).The incidence of complications such as one-time high intraocular pressure and retinal detachment in the study group was lower than that in the control group(P＜0.05).Conclusion Injection of ranibizumab before conventional vitrectomy is more effective in improving intraocular pressure,restoring visual acuity and reducing VEGF and IGF-1 levels in patients with DR and NVG,which is worthy of clinical reference.
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