Research Progress of Drug Therapies for Repeated Implantation Failure during in Vitro Fertilization/Intracytoplasmic Sperm Injection
Repeated implantation failure(RIF)during in vitro fertilization/intracytoplasmic sperm in-jection(IVF/ICSI)is a challenge in the field of reproductive medicine.At present,there are many stud-ies on drug therapies for RIF,and immune factors play an important role in embryo implantation and preg-nancy maintenance,empirical immune-related drug therapies can improve pregnancy outcomes in some RIF patients.Therapeutic drugs include low molecular weight heparin(LMWH),granulocyte colony-stimu-lating factor(G-CSF),hydroxychloroquine sulfate(HCQ),cyclosporine A(CsA),and tumor necrosis factor α(TNF-α)inhibitors,platelet-rich plasma(PRP),peripheral blood mononuclear cell(PBMC),intravenous immunoglobulin(IVIG),fat emulsions,etc.The research progress on the treatments above is reviewed,in order to provide reference for clinical treatment.
In vitro fertilization-embryo transferIntracytoplasmic sperm injectionRepeated implan-tation failureDrug therapy
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