Flexible peak regulation operation and fuel property change of thermal power unit will lead to time-varying nonlinearity of the controlled object,and the equivalent model is equivalent to superimposing a time-varying dynamic element on the original model.This link has the characteristics of inertia,time delay or non-minimum phase under dif-ferent working conditions,and the traditional PID control is difficult to adapt to this kind of time-varying nonlinearity.In this paper,we proposed a flexible multi-model predictive control scheme,and established the dynamic models of in-ertia,time delay and non-minimum phase characteristics of the object under typical changed conditions.According to the changes of power load and coal quality,the control system can flexibly transfer between different models and their corresponding controllers.The simulation results show that this method can adapt to the strong change of object charac-teristics and ensure the stability of the control system in a large range with excellent control quality.The control scheme is applied to the coordinated control system of a circulating fluidized bed unit,and the overall control effect is satisfac-tory.