Nanoscale metal-organic frameworks for chemodynamic therapy of cancer
Currently,conventional cancer treatments such as chemotherapy(CT),radiotherapy(RT),and surgical remov-al exhibit limited efficacy and significant side effects,highlighting the critical need for innovative therapeutic strategies.Chemodynamic therapy(CDT),based on Fenton and Fenton-like reactions,novel approach that does not require external light or energy,thereby minimizing systemic side effects.CDT leverages the interaction between metal ions(Fe2+,Cu2+,Mn2+,Zn2+,Co2+)and excess hydrogen peroxide(H2O2)in the tumor microenvironment(TME)to generate highly cytotoxic hydroxyl radicals(·OH)for eliminating cancer cells.As a non-invasive therapy,CDT has gained widespread application in cancer treatment.Metal-organic frameworks(MOFs),with their highly porous crystalline structures from the self-as-sembly of metal ions and organic ligands,have attracted significant interest in CDT research for their porosity,large sur-face area,catalytic sites,and biocompatibility.This review explores the contributions of various MOFs to tumor CDT ther-apy and examines methods to enhance CDT's effectiveness.Furthermore,the future development and challenges of CDT are also proposed based on recent progress.We hopes that this review will provide new insights and directions for future CDT research.
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